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Discover Supplement-Drug Interactions
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Last Updated: 2 years ago
supplement:
Progesterone
drug:
Tamoxifen
Research Papers that Mention the Interaction
“Conclusions: Tamoxifen , when administered only during the luteal phase of the menstrual cycle, significantly reduces the nuclear volume and mitotic activity of the epithelium.”
Effects of tamoxifen on the breast in the luteal phase of the menstrual cycle“ Progesterone blocked the number of specific binding sites of progesterone and the stimulatory effect provoked by tamoxifen.”
“Combined treatment with tamoxifen and progesterone caused apoptosis similar to that induced by treatment with progesterone alone and had no additional anti-cancer effect in ovarian cancer cells.”
“Therefore, we attempted to determine whether combined treatment with progesterone and tamoxifen has a synergistic effect on anti-cancer activity.”
“Therefore, we tested the growth and apoptosis activity of progesterone and tamoxifen and the anticancer effect of combined treatment of progesterone and tamoxifen in ovarian cancer cells.”
“ Tamoxifen and raloxifene reduce progesterone and estrogen receptor alpha expression significantly and to a similar extent in the non-neoplastic breast tissue of women of reproductive age.”
“Total loss of PR is linked to reduced benefit from tamoxifen in both the adjuvant and metastatic settings.”
“ Tamoxifen also induced transient increases in [Ca(2+)](cyt) concentrations but inhibited the effects of both estradiol and progesterone.”
“The inhibitory effects of tamoxifen , ICI-182780 and RU 4486 on [Ca(2+)](cyt) responses to estradiol and progesterone could be reversed with higher concentrations of estradiol and progesterone, respectively.”
“In both cell lines, testosterone, dihydrotesterone, oestradiol and progesterone significantly stimulated cell proliferation, and this was reversed by hydroxyflutamide, bicalutamide or tamoxifen.”
“It is known, however, that premenopausal women receiving tamoxifen develop very high cycling estrogen and progesterone levels, which is at least theoretically of concern.”
“It was shown that Tamoxifen was able to increase concentrations cytoplasmatic receptors to progesterone in the tumor.”
“In MCF-7 cells, estradiol (10(-8) M), progesterone (10(-6) M) and tamoxifen (10(-6) M) significantly increased 16 alpha-hydroxylase activity (estradiol; 21% progesterone 10% to 32%; tamoxifen 21% to 31%; P less than 0.01).”
“Synergistic effects were observed when the cells were successively exposed to tamoxifen and progesterone.”
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