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Discover Supplement-Drug Interactions
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Last Updated: 3 years ago
supplement:
Progesterone
drug:
Suramin
Research Papers that Mention the Interaction
“ Suramin inhibited the production of testosterone by isolated rat Leydig cells as well as the conversion of pregnenolone to progesterone by the 3 beta-hydroxysteroid dehydrogenase enzyme extracted from rat testes, with 50% inhibitory concentrations (IC50 values) of 108.2 and 87.5 micrograms/mL, respectively.”
Clinical and experimental evidence of inhibition of testosterone production by suramin.“The addition of suramin , previously reported to inhibit autocrine growth stimulation, accelerate the daily progesterone production of luteal cells apparently by switching on the early onset of differentiation.”
A novel steroidogenic role of suramin-blocked luteal cell growth factors.“In addition, suramin caused a parallel decrease in ACTH-stimulated pregnenolone, progesterone and corticosterone release, suggesting that suramin does not affect corticosteroidogenesis via an inhibition of its regulatory enzymes.”
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