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Discover Supplement-Drug Interactions

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Last Updated: 8 months ago

Possible Interaction: Progesterone and Suramin





Research Papers that Mention the Interaction

Suramin inhibited the production of testosterone by isolated rat Leydig cells as well as the conversion of pregnenolone to progesterone by the 3 beta-hydroxysteroid dehydrogenase enzyme extracted from rat testes, with 50% inhibitory concentrations (IC50 values) of 108.2 and 87.5 micrograms/mL, respectively.
The Journal of clinical endocrinology and metabolism  •  1996  |  View Paper
The addition of suramin , previously reported to inhibit autocrine growth stimulation, accelerate the daily progesterone production of luteal cells apparently by switching on the early onset of differentiation.
The Tohoku journal of experimental medicine  •  1992  |  View Paper
In addition, suramin caused a parallel decrease in ACTH-stimulated pregnenolone, progesterone and corticosterone release, suggesting that suramin does not affect corticosteroidogenesis via an inhibition of its regulatory enzymes.
Endocrinology  •  1990  |  View Paper