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Discover Supplement-Drug Interactions
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Last Updated: 5 years ago
supplement:
Progesterone
drug:
Substance P
Research Papers that Mention the Interaction
“This may be because progesterone and allopregnenolone reduce meningeal release of substance P and inhibit the development of neurogenic oedema.”
Differential effects of progestins on the brain.“In the anterior pituitary, the substance P content was increased after progesterone , and this increase was blocked by EB.”
“In the trigeminal nucleus, the substance P content was increased after progesterone and EB, while only progesterone affected neurokinin A content.”
“Injection with EB decreased the plasma concentration of substance P at the time of the positive feed‐back exerted by EB on gonadotropin … no effect on the plasma concentration of neurokinin A. In the hypothalamus, EB injection enhanced the substance P and neurokinin A content, while progesterone … substance P ….”
Ovarian Steroid Modulation of Neurokinin Contents in Hypothalamus, Pituitary, Trigeminal Nucleus, and Cervical Spinal Cord of the Ovariectomized Female Rat“attenuated the effects of progesterone after electrical stimulation and substance P administration.”
“SGnRH and SP decreased PGE2 and progesterone and increased PGF2 alpha by CL1 and CL2.”
“In the MDS, a 30-min perfusion with NPY, SP or VIP (10 nmol/l, 100 nmol/l and 1 mumol/l) induced significant acute effects on progesterone and oxytocin release.(ABSTRACT TRUNCATED AT 250 WORDS)”
“The stimulatory effect of progesterone on GnRH-induced LH release was reduced by treatment with SP.”
“These neuroanatomical data are consistent with the hypothesis that substance P may mediate some of the neural actions of progesterone.”
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