Possible Interaction: Progesterone and Steroids

“However, progesterone inhibits steroid binding to elephant shark GR, but not to human GR.”

“Although most steroid hormones had no or minor inhibitory effects on the dopamine formation by all CYP2D6 variants, progesterone inhibited the metabolism and Ki value against CYP2D6.10 was approximately twice that for CYP2D6.1 and CYP2D6.2.”

“Thus, hormones and locally produced factors including steroids , growth factors, cytokines, reactive oxygen species and nitric oxide may modulate luteal lifespan.”

“This novel mechanism of negative transcriptional regulation by oestradiol and progesterone decreases the production of ET-1, potentially contributing to the vascular protective effects of these steroids.”

“Moreover, we show new evidence suggesting a role for progesterone in regulating steroid hormone biosynthesis through regulation of the StAR gene.”

“The oral administration of progesterone , however, is compromised by individual differences in bioavailability and metabolism of the steroid.”

“Our data suggest that decorin expression in leiomyoma is inhibited by progesterone , which may be a mechanism by which the ovarian steroids affect leiomyoma growth and disease progression.”

“The diagnostic value of salivary oestradiol, progesterone , testosterone, dehydroepiandrosterone and aldosterone testing is compromised by rapid fluctuations in salivary concentrations of these steroids.”

“Flow cytometry studies of these cultures indicated a strong G2/M blocking effect of both steroids , either individually or in combination; the effects of progesterone and of both agents together were substantially greater than the effect with 17 beta-estradiol alone.”

“The uptake of progesterone was also inhibited by several neutral steroids but not by anionic steroids.”