Possible Interaction: Progesterone and Sodium Chloride

“Daily injections of NaCl reduced the levels of pregnenolone, progesterone , and corticosterone in the adrenal glands, increased corticosterone excretion with urine, enhanced activity of the first isoform of 11β-hydroxysteroid dehydrogenase in the liver and reduction in activity of the second isoform of this enzyme in the kidneys.”

“Both hormones had a differential effect on the ingestion of the two concentrations of glucose while progesterone markedly increased the intake of Sodium Chloride.”

“In animals treated with NaCl , the secretion of progesterone , 17alpha-hydroxyprogesterone, 11-deoxycortisol, aldosterone and corticosterone was decreased, while cortisone, pregnenolone, 7-keto-cholesterol, 7-keto-DHEA, DHEA and adrenosterone were increased.”

“While daily treatment with 1 mg progesterone was without influence on any of the parameters measured, this amount enhanced the effect of E2 on NaCl intake.”

“The exogenous addition of 10−6, 10−8 and 10−10 M progesterone to the stressing media in which bean seeds were germinated in combination with the salt (100 mM NaCl ) stressor induced significant protective changes in the germination and early growth parameters.”