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Discover Supplement-Drug Interactions
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Last Updated: 3 years ago
supplement:
Progesterone
drug:
Sirolimus
Research Papers that Mention the Interaction
“Increased progesterone production in response to treatment with human chorionic gonadotropin or forskolin was also blocked by rapamycin pretreatment.”
HCG-mediated activation of mTORC1 signaling plays a crucial role in steroidogenesis in human granulosa lutein cells“A twofold increase in S6 kinase activity occurred within 1 h of progesterone stimulation and rapamycin inhibited this activity.”
“Addition of rapamycin within 3 h, but not 6 h, of progesterone treatment inhibited GVBD.”
Inhibition of S6 kinase by rapamycin blocks maturation of Rana dybowskii oocytes.“ Rapamycin , an inhibitor of p70S6K activation, caused oocytes to undergo germinal vesicle breakdown earlier than control oocytes, and sensitivity to progesterone was increased.”
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