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Discover Supplement-Drug Interactions
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Last Updated: 3 years ago
supplement:
Progesterone
drug:
Simvastatin
Research Papers that Mention the Interaction
“Moreover, simvastatin significantly decreased secretion of progesterone from the placental explants (P < 0.01).”
Simvastatin has deleterious effects on human first trimester placental explants.“Now, lovastatin and simvastatin , which strongly inhibited sterol synthesis, significantly attenuated the secretion of progesterone.”
“So under conditions in which the cholesterol pools were decreased, lovastatin and simvastatin attenuated the progesterone secretion, whereas pravastatin did not.”
“ Simvastatin , a potent inhibitor of the key enzyme controlling de novo cholesterol synthesis, 3-hydroxy-3-methylglutaryl-coenzyme A (HMG-CoA) reductase, completely inhibited (P < 0.05) progesterone production by granulosa cells and progesterone and androstenedione production by thecal cells.”
Insulin-like growth factor I enhancement of steroidogenesis by bovine granulosa cells and thecal cells: dependence on de novo cholesterol synthesis.“ Simvastatin lowered luteal progesterone concentrations only in WHHL rabbits (P < 0.05).”
“Additionally, simvastatin reduced the expression of Wnt4 and total β-catenin, as well as non-phosphorylated β-catenin protein expression in response to estrogen and progesterone.”
Simvastatin inhibits Wnt/β-catenin pathway in uterine leiomyoma.
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