Allen Institute for Artificial Intelligence
supp.ai logo
supp.ai

Discover Supplement-Drug Interactions

Disclaimer: The information contained herein should NOT be used as a substitute for the advice of an appropriately qualified and licensed physician or other health care provider. The tool is not a substitute for the care provided… (more)
Last Updated: 8 months ago

Possible Interaction: Progesterone and Simvastatin

supplement:

Progesterone

Research Papers that Mention the Interaction

Moreover, simvastatin significantly decreased secretion of progesterone from the placental explants (P < 0.01).
Human reproduction  •  2005  |  View Paper
Now, lovastatin and simvastatin , which strongly inhibited sterol synthesis, significantly attenuated the secretion of progesterone.
So under conditions in which the cholesterol pools were decreased, lovastatin and simvastatin attenuated the progesterone secretion, whereas pravastatin did not.
Biochimica et biophysica acta  •  1996  |  View Paper
Simvastatin , a potent inhibitor of the key enzyme controlling de novo cholesterol synthesis, 3-hydroxy-3-methylglutaryl-coenzyme A (HMG-CoA) reductase, completely inhibited (P < 0.05) progesterone production by granulosa cells and progesterone and androstenedione production by thecal cells.
The Journal of endocrinology  •  1996  |  View Paper
Simvastatin lowered luteal progesterone concentrations only in WHHL rabbits (P < 0.05).
Journal of lipid research  •  1994  |  View Paper
Additionally, simvastatin reduced the expression of Wnt4 and total β-catenin, as well as non-phosphorylated β-catenin protein expression in response to estrogen and progesterone.
Endocrinology  •  2021  |  View Paper