Possible Interaction: Progesterone and Serotonin

“ Progesterone significantly increased 5-hydroxytryptamine concentrations in the mid- and hindbrain; there was also some evidence of an increase in the cortex.”

“ Progesterone injections did not influence NA turnover or percentage distribution of tritiated-NA and its metabolites in unstressed rats but did increase 5-HT turnover.”

“Treatments for infertility may independently influence mood through their effects on estrogen and progesterone , which have been shown to influence mood through their actions on serotonin.”

“The present study shows that the gonadal steroids, 17beta-estradiol and progesterone , may also act as functional antagonists at the 5-hydroxytryptamine type 3 (5-HT3) receptor in whole-cell voltage-clamp recordings of HEK 293 cells stably expressing the 5-HT3 receptor.”

“Both melatonin and serotonin were potent inhibitors of progesterone release.”

“… progesterone … 5-HT (r = 0.67) and between NA and DA (r = 0.93) in the pregnant group; between progesterone and E2 (r = 0.84) in …) and between NA and DA (r = 0.62) in FF from cycles in which the oocyte cleaved but did not result in pregnancy.”

“In particular, both estrogen and progesterone have profound effects on the serotonin , norepinephrine, dopamine, and endorphin receptor systems that are involved in mood regulation.”

“Using an in vitro assay of an explant of mature ovary, it was shown that 5-HT was able to enhance ovarian estradiol-17β (E2) and progesterone (P4) secretions.”

“In addition, we found that progesterone protects serotoninergic neurons in monkeys, leading us to question whether ovarian steroids are also neuroprotective in LC neurons in monkeys.”

“ Progesterone pretreatment enhanced the stimulatory action of serotonin on BDNF gene expression, and the enhancement of serotonin action observed in the cells pretreated with progesterone was almost completely abolished by finasteride, an inhibitor of the enzyme involved in the production of 5α-reduced neurosteroids.”