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Last Updated: 8 months ago

Possible Interaction: Progesterone and Serotonin



Research Papers that Mention the Interaction

Progesterone significantly increased 5-hydroxytryptamine concentrations in the mid- and hindbrain; there was also some evidence of an increase in the cortex.
Psychopharmacologia  •  2006  |  View Paper
Progesterone injections did not influence NA turnover or percentage distribution of tritiated-NA and its metabolites in unstressed rats but did increase 5-HT turnover.
Psychoneuroendocrinology  •  1977  |  View Paper
Treatments for infertility may independently influence mood through their effects on estrogen and progesterone , which have been shown to influence mood through their actions on serotonin.
Human reproduction update  •  2007  |  View Paper
The present study shows that the gonadal steroids, 17beta-estradiol and progesterone , may also act as functional antagonists at the 5-hydroxytryptamine type 3 (5-HT3) receptor in whole-cell voltage-clamp recordings of HEK 293 cells stably expressing the 5-HT3 receptor.
Molecular endocrinology  •  1998  |  View Paper
Both melatonin and serotonin were potent inhibitors of progesterone release.
Experimental and clinical endocrinology & diabetes : official journal, German Society of Endocrinology [and] German Diabetes Association  •  1997  |  View Paper
progesterone … 5-HT (r = 0.67) and between NA and DA (r = 0.93) in the pregnant group; between progesterone and E2 (r = 0.84) in …) and between NA and DA (r = 0.62) in FF from cycles in which the oocyte cleaved but did not result in pregnancy.
Gynecologic and obstetric investigation  •  1993  |  View Paper
In particular, both estrogen and progesterone have profound effects on the serotonin , norepinephrine, dopamine, and endorphin receptor systems that are involved in mood regulation.
NAACOG's clinical issues in perinatal and women's health nursing  •  1991  |  View Paper
Using an in vitro assay of an explant of mature ovary, it was shown that 5-HT was able to enhance ovarian estradiol-17β (E2) and progesterone (P4) secretions.
Invertebrate Neuroscience  •  2018  |  View Paper
In addition, we found that progesterone protects serotoninergic neurons in monkeys, leading us to question whether ovarian steroids are also neuroprotective in LC neurons in monkeys.
Brain Research  •  2017  |  View Paper
Progesterone pretreatment enhanced the stimulatory action of serotonin on BDNF gene expression, and the enhancement of serotonin action observed in the cells pretreated with progesterone was almost completely abolished by finasteride, an inhibitor of the enzyme involved in the production of 5α-reduced neurosteroids.
Journal of Molecular Neuroscience  •  2007  |  View Paper
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