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Last Updated: 3 months ago

Possible Interaction: Progesterone and Propylthiouracil

Research Papers that Mention the Interaction

However, our present results indicate that a 16-h treatment with PTU was able to stimulate pregnenolone production in rat granulosa cells, although progesterone production was diminished by PTU through inhibition of 3β-hydroxysteroid dehydrogenase.
In conclusion, these results indicate that PTU plays opposite roles in the production of progesterone and its precursor, pregnenolone.
Our previous study demonstrated that short-term treatment with PTU inhibits progesterone production in rat granulosa cells.
Toxicological sciences : an official journal of the Society of Toxicology  •  2010  |  View Paper
PTU (12 mM) inhibited the activities of both the cytochrome P450 side‐chain cleavage enzyme (P450scc, conversion of 25‐hydroxyl cholesterol to pregnenolone) and the 3β‐hydroxysteroid dehydrogenase (conversion of pregnenolone to progesterone ) in rat granulosa cells.
PTU (3–12 mM) decreased the basal and human chorionic gonadotropin (hCG)‐stimulated release of progesterone from rat granulosa cells.
The present results suggest that PTU decreases the progesterone release by granulosa cells via a thyroid‐independent mechanism involving the inhibition of post‐cAMP pathway, and the activities of intracellular calcium, steroidogenic enzyme, and StAR protein functions.
British journal of pharmacology  •  2003  |  View Paper