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Discover Supplement-Drug Interactions
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Last Updated: 3 years ago
supplement:
Progesterone
drug:
Propylthiouracil
Research Papers that Mention the Interaction
“However, our present results indicate that a 16-h treatment with PTU was able to stimulate pregnenolone production in rat granulosa cells, although progesterone production was diminished by PTU through inhibition of 3β-hydroxysteroid dehydrogenase.”
“In conclusion, these results indicate that PTU plays opposite roles in the production of progesterone and its precursor, pregnenolone.”
“Our previous study demonstrated that short-term treatment with PTU inhibits progesterone production in rat granulosa cells.”
Stimulatory effects of propylthiouracil on pregnenolone production through upregulation of steroidogenic acute regulatory protein expression in rat granulosa cells.“ PTU (12 mM) inhibited the activities of both the cytochrome P450 side‐chain cleavage enzyme (P450scc, conversion of 25‐hydroxyl cholesterol to pregnenolone) and the 3β‐hydroxysteroid dehydrogenase (conversion of pregnenolone to progesterone ) in rat granulosa cells.”
“ PTU (3–12 mM) decreased the basal and human chorionic gonadotropin (hCG)‐stimulated release of progesterone from rat granulosa cells.”
“The present results suggest that PTU decreases the progesterone release by granulosa cells via a thyroid‐independent mechanism involving the inhibition of post‐cAMP pathway, and the activities of intracellular calcium, steroidogenic enzyme, and StAR protein functions.”
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