Possible Interaction: Progesterone and Propranolol

“Norepinephrine but not epinephrine dependent progesterone secretion was blocked by propranolol.”

“The increase in the progesterone level can be blocked by the /3-receptor blocking agent, propranolol (Fylling 1971¿).”

“Downloaded from Bioscientifica.com at 11/16/2018 11:10:10PM via free access sin infusion on the plasma progesterone levels would be inhibited by propranolol , a /3-blocking agent.”

“ Propranolol blocked the influence of NE and ISO on progesterone production.”

“Cyclosporin A, progesterone , rhodamine 123, verapamil,4E3 mAb and 2,4-DNP all increased apical 50 nM propranolol uptakeby 43% to 66%.”

“Basal secretion of progesterone is partly dependent on constant beta-adrenergic stimulation since local infusion of propranolol (beta-blocker) into the ovary decreased progesterone secretion by 20-30% of pre-treatment value.”

“Similarly, propranolol stimulated progesterone production 2.2-fold.”

“Moreover, the findings suggest that estrogen induces an increase in the number of beta-receptor sites, whereas progesterone increases the apparent propranolol sensitivity for these receptor sites.”

“In the present study, both the (-) and (+) optical isomers of propranolol were effective in inhibiting lordosis behavior in ovariectomized rats treated with estrogen and progesterone.”

“The isoproterenol-induced progesterone production could not be blocked by butoxamine (10(-5) M, a beta 2-antagonist), or practolol (10(-5) M, a beta 1-antagonist), but was inhibited by propranolol (10(-5) M, a general beta-antagonist; P less than 0.05).”