Possible Interaction: Progesterone and Polypeptides

“Using various pharmacological inhibitors of degradation pathways, we showed that progesterone-associated degradation of SERCA2a involves ubiquitination, and progesterone significantly decreases the levels of ubiquitin-tagged SERCA2a polypeptides.”

“OBJECTIVES Polypeptide growth factors may modulate the actions of estrogen (E2) and progesterone (P) in reproductive tissues in an autocrine/paracrine manner.”

“The purified polypeptide dose-dependently inhibited production of both estradiol (EC50 = 0.7 nM) and progesterone (EC50 = 1.3 nM) by rat granulosa cells cultured in the presence of 20 ng/ml FSH.”

“Early progesterone stimulation altered the synthesis and release of polypeptides from endometrial explant cultures on Day 5.”

“These findings suggest an association of progesterone binding with conformational changes of the polypeptide structure of uteroglobin.”

“A secondary injection with progesterone increases the amounts of highly labelled polypeptides with a molecular weight of over 70,000 daltons.”