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Discover Supplement-Drug Interactions
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Last Updated: 3 years ago
supplement:
Progesterone
drug:
Paclitaxel
Research Papers that Mention the Interaction
“Conclusion: Progesterone had a statistically significant impact on the pharmacokinetics of paclitaxel.”
“High-dose progesterone increased the peak plasma levels (3.00 ± 0.94 vs. 4.15 ± 1.63 M; P=0.029; mean ± SD) and the area under the curve (AUC; 14.3 ± 4.75 vs. 17.3 ± 5.59 M × h; P=0.006) of paclitaxel.”
A phase II/pharmacokinetic trial of high-dose progesterone in combination with paclitaxel“Overall, the findings indicate that circulating 17β-estradiol and progesterone contribute to the modulation of neuropathic pain response after administration of paclitaxel , likely via PIC signal in the sensory nerves, which is implicated to consider sex difference for pain management with application of chemotherapeutic paclitaxel.”
Effects of female sex hormones on chemotherapeutic paclitaxel-induced neuropathic pain and involvement of inflammatory signal.“In addition, taxol significantly increased the progesterone ED50 for GVD induction.”
“ Taxol inhibited centrifugation-induced GVM either alone or in the presence of progesterone.”
“ Taxol , an agent that stabilizes microtubules, markedly reduced FSH-stimulated progesterone production in both E2- and PMS-cells, but failed to exert a comparable effect on basal steroid production.”
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