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Discover Supplement-Drug Interactions

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Last Updated: 8 months ago

Possible Interaction: Progesterone and Mevastatin

supplement:

Progesterone

Research Papers that Mention the Interaction

Under these conditions, compactin , a competitive inhibitor of de novo endogenous cholesterol biosynthesis, suppressed stimulated progesterone production by approximately equal to 50%.
The Journal of biological chemistry  •  1987  |  View Paper
Compactin , a competitive inhibitor of HMG CoA reductase, inhibited progesterone production relatively little when cells were exposed to complete plasma or LF.
However, when cells were exposed to a lipoprotein-deficient bovine plasma or LF, compactin was very efficient in reducing (by 76%) progesterone release.
Endocrinology  •  1982  |  View Paper
Mevastatin (5 micromol), an inhibitor of the enzyme hydroxymethylglutaryl-CoA reductase and thus of cholesterol biosynthesis, gave an 85% decrease in the production of (14)C-DLIF and progesterone , but only a modest 15% decrease in (14)C-Dh-DLIF production.
Clinical chemistry  •  2004  |  View Paper