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Discover Supplement-Drug Interactions
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Last Updated: 3 years ago
supplement:
Progesterone
drug:
Mevastatin
Research Papers that Mention the Interaction
“Under these conditions, compactin , a competitive inhibitor of de novo endogenous cholesterol biosynthesis, suppressed stimulated progesterone production by approximately equal to 50%.”
Mechanisms subserving the steroidogenic synergism between follicle-stimulating hormone and insulin-like growth factor I (somatomedin C). Alterations in cellular sterol metabolism in swine granulosa cells.“ Compactin , a competitive inhibitor of HMG CoA reductase, inhibited progesterone production relatively little when cells were exposed to complete plasma or LF.”
“However, when cells were exposed to a lipoprotein-deficient bovine plasma or LF, compactin was very efficient in reducing (by 76%) progesterone release.”
“ Mevastatin (5 micromol), an inhibitor of the enzyme hydroxymethylglutaryl-CoA reductase and thus of cholesterol biosynthesis, gave an 85% decrease in the production of (14)C-DLIF and progesterone , but only a modest 15% decrease in (14)C-Dh-DLIF production.”
De novo biosynthesis and radiolabeling of mammalian digitalis-like factors.
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