Possible Interaction: Progesterone and Medroxyprogesterone Acetate

“CONCLUSIONS The … pr gesterone co uld inhibit the growth, promote apoptosis and inhibit metastasis of endometrial carcinoma, MIF could inhibit the growth and … more strongly inhibit the growth, promote apoptosis and inhibit metastasis of endometrial carcinoma than MIF or MPA , a nd synergistic effect was observed on …, PR, bax and bcl-2.”

“The progesterone resistance is counteracted by progestins ( Medroxyprogesterone acetate , Dienogest, Danazol, Levonorgestrel) or by Selective progesterone receptor modulators, a class of drugs under development.”

“Consequently, progesterone , the name of an individual hormone, should not be used as a synonym for MPA.”

“The central hypothesis examined … this paper is that MPA more so than … concentrations of progesterone (P4) is likely to repress immune function at doses within the range found in the serum of … users due to its potent glucocorticoid-like immunosuppressive properties which could influence the pathogenicity of infectious diseases.”

“In the presence of progesterone , progesterone receptor A (PRA) interacts with the G protein Gα13, while MPA drives PR to interact with tyrosine kinase c-Src and to activate phosphatidylinositol-3 kinase, leading to the activation of RhoA/ROCK-2.”

“Overlapping in gene regulation by progesterone and MPA occurred, but the majority of genes regulated by these hormones were distinct.”

“Combined treatment with two progestins was superior to single progestin treatment, with progesterone plus medroxyprogesterone acetate (MPA) achieving over 85% cell kill in both TRAIL‐sensitive and ‐resistant OCa cell lines.”

“ Progesterone inhibits the 21-hydroxylation of 17α-hydroxyprogesterone by human adrenal cortex microsomes.”

“Consistent with the regulation by progesterone of the decidualization process in vivo, medroxy-progesterone acetate elevated the tissue factor content of primary stromal cell cultures 8-fold over basal values.”

“The in vitro growth of cells derived … tumors after relapse under treatment with medroxyprogesterone acetate or tamoxifen was … enhanced by progesterone or tamoxifen (CAS: 10540-29-1) in concentrations corresponding to therapeutical serum levels and in accordance with in vivo resistance to the endocrine therapy applied before cell sampling.”