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“The 10 women with … syndrome who were given leuprolide plus … or progesterone had a significant recurrence of symptoms, but no changes in mood occurred in 15 normal women who received the same regimen or in 5 women with premenstrual syndrome who were given placebo hormone during continued leuprolide administration.”
“In vitro, testosterone, estradiol and progesterone were also reduced by LA , even though this reduction occurred for progesterone only at the highest LA dosage (10(-6)M; 606.0+/-114.3 ng/ml versus 1524.0+/-246.5 ng/ml; p=0.02).”
“ Leuprolide formulation caused a decrease in concentrations of LH and progesterone , temporary suppression of ovulation and steroidogenesis, and effective contraception (100%) for one breeding season.”