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Discover Supplement-Drug Interactions
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Last Updated: 5 years ago
supplement:
Progesterone
drug:
Leptin
Research Papers that Mention the Interaction
“High leptin concentration suppressed both basal estradiol and progesterone productions in GC.”
Leptin Affects Pregnancy Outcome of In Vitro Fertilization and Steroidogenesis of Human Granulosa Cells“Natural progesterone , a potent respiratory stimulant, stimulates leptin production in premenopausal females.”
“Moreover, oestrogen and progesterone can stimulate leptin secretion in women of reproductive age.”
“ Leptin or BIIE0246 treatment significantly increased E2, but notably decreased progesterone in both mice.”
“For the first time, inverse regressions suggest inhibitory effects of leptin on NF-κB p65 activation at luteal phase, along with inhibitory effects of leptin as well as adiponectin on progesterone production in corpus luteum.”
“ Leptin inhibits the secretion of progesterone by cytotrophoblast.”
“Serum leptin concentration negatively correlated with LH and progesterone (P<0.05).”
“We show that leptin inhibits 8-bromo cAMP-stimulated progesterone production in a concentration-dependent manner.”
“In particular, leptin at low concentrations stimulated the secretion of estradiol (1 and 10 ng/ml) and progesterone (10 ng/ml), while at a high concentration (100 ng/ml) it suppressed the secretion of both steroids.”
“Results: Leptin affected basal estradiol and progesterone secretion in a dose-related manner.”
“Treatment with hPL and progesterone led to a time- and dose-dependent decrease in leptin release that was statistically significant after 24 h, with a maximal effect after 72 h of incubation.”
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