Possible Interaction: Progesterone and Ghrelin

“ Ghrelin was correlated negatively with HOMA-IR (P < 0.001), 17 OH progesterone (P = 0.05), total (P = 0.015) and free testosterone (P = 0.013).”

“All of the investigated ghrelin concentrations decreased progesterone (P(3)) but had no effect on human chorionic gonadotrophin (hCG) secretion.”

“Both basal and hCG-stimulated P release was significantly decreased by ghrelin , which was able to reduce PGE(2) and increase PGF(2alpha) luteal release.”

“The mRNA and protein expression of ghrelin and GHS-R1a was significantly greater in mid- and late luteal phases.”

“Additions of FSH, IGF-I and ghrelin to culture medium reduced the release of progesterone and increased testosterone and estradiol output by fragments isolated from control animals.”

“In conclusion, the presence of ghrelin and its receptor in porcine corpora lutea and the direct inhibitory effects of ghrelin on luteal P4 secretion and 3β-HSD suggest potential auto/paracrine regulation by ghrelin in the luteal phase of ovary function.”

“ Ghrelin promoted proliferation (PCNA, cyclin B1, MAPK) and progesterone secretion but suppressed apoptosis (Bax, caspase 3, p53).”

“Results demonstrated that Ghrelin60 increased progesterone concentration, reduced CC viability, induced CC DNA damage, and decreased blastocyst and hatching rate compared with C (P < 0.05).”