Possible Interaction: Progesterone and Gaba Agents

“The 3alpha,5alpha- and 3alpha,5beta-reduced derivatives of progesterone , deoxycorticosterone, dehydroepiandrosterone and testosterone enhance GABAergic neurotransmission and produce inhibitory neurobehavioral and anti-inflammatory effects.”

“They found that progesterone stimulated increased intracellular Ca2+ concentrations in a process that required the nonselective cationic channel TRPV4 and the stepwise activation of GABAA and GABAB receptors, which physically associated with each other in response to progesterone and GABAergic agonists.”

“Female sex steroid homones - both estrogens and progesterone - affect functioning of GABAergic system.”

“The results indicate that GABA‐ergic progesterone metabolites modulate nociception.”

“Our study provides strong evidence that the protective effect of progesterone resides in the GABAergic as well as neuroprotective activity of its metabolite allopregnanolone.”

“The possibility that progesterone may impair learning and to some extent, retention by facilitating the GABAergic activity and thereby reducing arousal level is discussed.”

“Estradiol or progesterone may alter cognitive performance and seizure activity by increasing or decreasing, respectively, the activity of GABAergic neurons in the hippocampus.”

“In aged ovariectomized (Ovx) rats, progesterone has been shown to impair cognition and impact the GABAergic system in cognitive brain regions.”