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Last Updated: 9 months ago

Possible Interaction: Progesterone and Gaba Agents

supplement:

Progesterone

Research Papers that Mention the Interaction

The 3alpha,5alpha- and 3alpha,5beta-reduced derivatives of progesterone , deoxycorticosterone, dehydroepiandrosterone and testosterone enhance GABAergic neurotransmission and produce inhibitory neurobehavioral and anti-inflammatory effects.
Steroids  •  2009  |  View Paper
They found that progesterone stimulated increased intracellular Ca2+ concentrations in a process that required the nonselective cationic channel TRPV4 and the stepwise activation of GABAA and GABAB receptors, which physically associated with each other in response to progesterone and GABAergic agonists.
Science Signaling  •  2018  |  View Paper
Female sex steroid homones - both estrogens and progesterone - affect functioning of GABAergic system.
Acta neurobiologiae experimentalis  •  2014  |  View Paper
The results indicate that GABA‐ergic progesterone metabolites modulate nociception.
PAIN  •  2008  |  View Paper
Our study provides strong evidence that the protective effect of progesterone resides in the GABAergic as well as neuroprotective activity of its metabolite allopregnanolone.
Progress in Neuro-Psychopharmacology and Biological Psychiatry  •  2008  |  View Paper
The possibility that progesterone may impair learning and to some extent, retention by facilitating the GABAergic activity and thereby reducing arousal level is discussed.
Physiology & Behavior  •  1995  |  View Paper
Estradiol or progesterone may alter cognitive performance and seizure activity by increasing or decreasing, respectively, the activity of GABAergic neurons in the hippocampus.
Endocrinology  •  1992  |  View Paper
In aged ovariectomized (Ovx) rats, progesterone has been shown to impair cognition and impact the GABAergic system in cognitive brain regions.
Front. Aging Neurosci.  •  2015  |  View Paper