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Last Updated: 2 months ago

Possible Interaction: Progesterone and Finasteride



Research Papers that Mention the Interaction

Finally, finasteride did not only affect, as expected, the levels of 5alpha-reduced metabolites of progesterone and testosterone, but also the further metabolites and precursors suggesting that this drug has broad consequence on neuroactive steroid levels of PFS patients.
The Journal of Steroid Biochemistry and Molecular Biology  •  2017  |  View Paper
Due to the capability of finasteride to block the metabolism of progesterone (PROG) and/or testosterone (T) we have evaluated, by liquid chromatography-tandem mass spectrometry, the levels of several neuroactive steroids in paired plasma and cerebrospinal fluid (CSF) samples obtained from post-finasteride patients and in healthy controls.
The Journal of Steroid Biochemistry and Molecular Biology  •  2015  |  View Paper
Finasteride treatment resulted in a significant decrease all alpha-reduced and increase of most 5beta-reduced metabolites of testosterone and progesterone as well as in an increase of 7alpha-hydoxyderivatives, which are known as neuroactive steroids acting by modulation of GABAA and NMAD receptors in the brain.
Prague medical report  •  2009  |  View Paper
The protective effect of progesterone was abolished in the presence of finasteride , a 5α-reductase inhibitor, suggesting it was largely mediated via its conversion to allopregnanolone.
BMC neuroscience  •  2020  |  View Paper
Blocking progesterone ’s metabolism to 5α -pregnan-3α -ol-20-one (3α ,5α -THP) with finasteride , a 5α -reductase inhibitor, and effects on anxiolytic, exploratory, and antinociceptive behaviors of rats in behavioral estrus were examined.
Cognitive, affective & behavioral neuroscience  •  2001  |  View Paper
While the neuroprotection conferred by progesterone was not affected by SU-10603, an inhibitor of cytochrome P45017α, finasteride , a 5α-reductase inhibitor that blocks the conversion of progesterone to allopregnanolone, partially reversed the neuroprotection induced by progesterone.
Steroids  •  2016  |  View Paper
Prior administration of finasteride decreased allopregnanolone concentrations and abolished the increase in proceptivity induced by progesterone administration.
Psychopharmacology  •  2014  |  View Paper
In brain slices, progesterone at 1μM inhibited entorhinal epileptiform potentials in the presence of picrotoxin and finasteride.
Neuroscience  •  2014  |  View Paper
The neuroprotective action of progesterone was completely canceled with pretreatment by finasteride , a 5α-reductase inhibitor, but it was not affected by mifepristone, a progesterone receptor antagonist, or by SU-10603, a cytochrome P450 17α inhibitor.
The Journal of Steroid Biochemistry and Molecular Biology  •  2013  |  View Paper
Initially, we confirmed, that both progesterone and AlloP were protective in terms of reducing cell death following … concentration of 0.1μM. However, the protective effect of progesterone was absent in the presence of finasteride (… progesterone to active metabolites, including AlloP. In addition, … seen by either progesterone or AlloP alone.
Neuroscience Letters  •  2012  |  View Paper
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