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Discover Supplement-Drug Interactions
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Last Updated: 5 years ago
supplement:
Progesterone
drug:
Epoprostenol
Research Papers that Mention the Interaction
“Gossypol acetate, progesterone and danazol inhibit PGI2 and TXB2 content in endometrial cell of patients with endometriosis.”
[Effects of gossypol and GnRHa on the prostaglandins contents of endometriotic cell and in situ].“A progesterone concentration of 1.5 x 10(-5) mol/L significantly (p less than 0.001) inhibited prostacyclin production, compared with control, but lower concentrations did not.”
“CONCLUSION In vitro addition of pr gesterone at a concentration equivalent to that in the medium after incubation of preeclamptic placentas inhibited pro stacyclin pr oduction by normal placentas to a rate characteristic of preeclampsia.”
“Higher concentrations of progesterone in the preeclamptic placenta could contribute to lower prostacyclin production because progesterone inhibits placental prostacyclin production.”
“Angiogenic factors are found in luteal tissue and prostacyclin increases luteal blood flow.”
“ Progesterone , for example, inhibits PGI2 production.”
“Moreover, prostacyclin stimulated progesterone production and this effect was abolished by the addition of prostacyclin receptor antagonists.”
Prostacyclin synthesis and prostacyclin receptor expression in the porcine corpus luteum: evidence for a luteotropic role in vitro†“Using aortic strips isolated from female fertile Wistar rats, we showed that physiological concentrations of progesterone markedly increase prostacyclin synthesis in a very short time interval (45 s to 10 min) as well as nitric oxide release (5-30 min).”
“It is suggested that overnight treatment of the epithelial cells with progesterone increases the amount or activity of prostacyclin synthetase, responsible for converting PGH2 endoperoxide to PGI2.”
“It is concluded from these studies that progesterone can modulate luteal prostacyclin and PGF2 alpha synthesis, suggesting an interaction of progesterone and prostaglandin production within the corpus luteum.”
“… PGI2 … progesterone ; PGI2 stimulated synthesis of progesterone by dispersed luteal cells; synthesis of PGI2 by luteal cells was greatest during the period of early CL development (…-HETE to dispersed luteal cells inhibited synthesis of progesterone and PGI2, while production of PGF2 alpha was unaffected.(ABSTRACT TRUNCATED AT 250 WORDS)”
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