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Discover Supplement-Drug Interactions

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Last Updated: 8 months ago

Possible Interaction: Progesterone and Dutasteride



Research Papers that Mention the Interaction

Dutasteride (10(-6)M) inhibited progesterone conversion to 5alpha-pregnanes by >95% and increased 4-pregnene production.
The Journal of Steroid Biochemistry and Molecular Biology  •  2006  |  View Paper
Although 5α-reduced metabolites were unchanged, these data suggest an accumulation of precursor progesterone with inhibition of 5α-reductase, indicating the ability of dutasteride to alter progesterone metabolism.
Dutasteride concentrations increased in the treated mares, with a significant correlation (P < 0.05) between dutasteride concentrations and pregnenolone or progesterone concentrations.
Reproduction  •  2018  |  View Paper
Dutasteride treatment by inhibiting transformation of progesterone and testosterone to its metabolites elevated plasma and brain concentrations of testosterone compared to MPTP mice and decreased DHT levels in intact mice.
The Journal of Steroid Biochemistry and Molecular Biology  •  2017  |  View Paper