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Discover Supplement-Drug Interactions
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Last Updated: 3 years ago
supplement:
Progesterone
supplement:
Docosahexaenoic Acid
Research Papers that Mention the Interaction
“ DHA positively affected oestrogen and progesterone concentrations and diminished cortisol concentrations only in oestrus.”
Steroid hormone concentrations and body mass are differently affected by polyunsaturated fatty acids during the oestrous cycle in guinea pigs.“The addition of DHA-sulfate and DHA inhibited 20 alpha-HSD activity for progesterone significantly, suggesting that the steroid produced by the feto-placental unit may be involved in the metabolism of progesterone in human placenta.”
“ DHA … progesterone secretion at 1, 20 and 50 μM, and estradiol secretion at 1, 10 and 20 μM. Consistent increases in protein levels were also reported … delta-isomerase 1 (HSD3B1), and of the cholesterol transporter steroidogenic acute regulatory protein (StAR), which are necessary for production of progesterone or androstenedione.”
Docosahexaenoic acid (DHA) effects on proliferation and steroidogenesis of bovine granulosa cells“As was shown by real-time … reaction, negative effects of 100-μM DHA were associated … increase of progesterone synthesis by oocyte-cumulus complexes, a three-fold increase in expression level of FA transporter CD36 … two-fold decrease of FA synthase FASN genes in cumulus cells (CCs) of corresponding oocytes.”
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