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Last Updated: 8 months ago

Possible Interaction: Progesterone and Dihydrotestosterone

Research Papers that Mention the Interaction

The primary effect is the abolition … action of phenolic estrogens and progesterone … dihydrotestosterone is administered concurrently, presumably through direct action at the tumor cell level A secondary contributory suppressive effect is the depression of ovarian activity, and consequently of the production of phenolic estrogens and progesterone, by these compounds.
The Journal of experimental medicine  •  1957  |  View Paper
Progesterone , at the level of the hair follicle, decreases the conversion of testosterone into DHT.
International journal of molecular sciences  •  2020  |  View Paper
As a consequence of … important observation that progesterone and deoxycortisone inhibits the synthesis of DHT by competing with 4-en-3-one function of the testosterone for the 5alpha-reductase enzyme a number of pregnane derivatives were synthesized and have been reported as inhibitors of human 5alpha-reductase enzyme.
Steroids  •  2010  |  View Paper
Oestrogens and androgens stimulate collagen matrix synthesis, while progesterone is a competitive inhibitor for the 5 alpha-reduction of testosterone to 5 alpha-dihydrotestosterone (DHT).
Progesterone inhibited DHT synthesis in HGF from 14C-testosterone by 24-62% (n = 8; p < 0.01).
Journal of periodontal research  •  2000  |  View Paper
Progesterone inhibited the formation of DHT and 4-A by 10-fold and 3-5-fold at effective inhibitory concentrations (n=4; p<0.001), when 14C- testosterone was used as substrate.
Journal of clinical periodontology  •  1999  |  View Paper
In genital skin fibroblasts, a 3 to … h of treatment of the cultures with dihydrotestosterone (DHT, 5 nM) whereas a 22 fold decrease is observed … increase is also observed after 1 h of treatment with progesterone (50 nM) or cyproterone acetate (500 nM) … as an antiandrogen in this model.
Annales d'endocrinologie  •  1991  |  View Paper
Dihydrotestosterone also inhibited progesterone production, but to a lesser extent than testosterone.
The Journal of clinical endocrinology and metabolism  •  1986  |  View Paper
The nonaromatizable androgen 5 alpha-dihydrotestosterone also inhibited progesterone production, but by no more than 45-50% even at supraphysiological concentrations.
The Journal of clinical endocrinology and metabolism  •  1983  |  View Paper
An inhibition of testosterone 5α-reduction to dihydrotestosterone was also observed after this percutaneous administration of progesterone.
The transformation of radioactive testosterone to dihydrotestosterone was inhibited by this in vitro addition of progesterone.
The Journal of clinical endocrinology and metabolism  •  1974  |  View Paper
DHT and T induced a concentration-dependent upregulation of Hsd3b and CYP11 expression, as well as increased progesterone concentrations in spent media.
Reproductive Sciences  •  2020  |  View Paper
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