Possible Interaction: Progesterone and Dehydroepiandrosterone Sulfate

“Tsui et al.’s experiment lends support to the theory that circulating DHEA-S in women on supplementation may alter serum progesterone levels.”

“… DHEA-S to the pooled serum of … in a linear increase in progesterone levels on two of three commercially available immunoassays (p < 0.05).ConclusionsDHEA-S can interfere with standard progesterone … programs, and thus serum progesterone levels in IVF patients on DHEA supplementation may not reflect truly bioactive progesterone.”

“Subsequent interaction studies indicated that progesterone only increases OATP2B1-mediated E(1)S and DHEAS transport, whereas uptake of BSP, atorvastatin and glibenclamide was either inhibited or not affected.”

“A positive correlation was found between circulating progesterone and DHEA-S levels (r = 0.50, p < 0.002 after adjustment for age).”

“The synthesis of dehydroepiandrosterone sulfate and the metabolism of progesterone , estrone, and estradiol are affected.”

“The addition of DHA-sulfate and DHA inhibited 20 alpha-HSD activity for progesterone significantly, suggesting that the steroid produced by the feto-placental unit may be involved in the metabolism of progesterone in human placenta.”

“The number of specific progesterone binding sites was increased 3.7-, 3.2-, and 2.0-fold by delta 5-diol, DHEA, and DHEAS , respectively.”

“ DHEAS inhibited output of progesterone (P less than .01) and PGF2 alpha (P less than .01).”

“DHA, DHA-S and 16-hydroxy-DHA stimulated oestrogen biosynthesis while high concentrations of DHA and DHA-S (but not 16-hydroxy-DHA) inhibited progesterone production.”

“In contrast, progesterone (PRGO) not only had no protective effect against the ischemic LTP impairment, but also attenuated the protective effect of DHEAS on the impaired LTP.”