Possible Interaction: Progesterone and Collagenases

“ Progesterone , which effectively inhibits collagenase production in rat uterine explant cultures, has no effect on human skin explants.”

“… progesterone (10-200 … release of collagenase , of total gelatinase activity, and of the active form of gelatinase B and largely inhibited the release of the active form of … were antagonized by mifepristone (RU 38486), suggest that progesterone restrains endometrial tissue breakdown by blocking the secretion and activation of MMPs.”

“During luteal development (Day 1 of pseudopregnancy), activity of both collagenase (p = 0.009) and gelatinase (p = 0.0003), but not proteoglycanase (p > or = 0.05), was significantly greater than at all other time points.”

“These data indicate that transcription of collagenase mRNA in myometrial smooth muscle cells is stimulated by serotonin, possibly via activation of protein kinase C, but is in some way prevented by the negative influence of progesterone.”

“The results of this study support the concept that progesterone plays a major role in preventing the production of collagenase in the rat uterus.”

“LH and progesterone added to cultures of the follicle wall of hens increased the total activity of neutral and acid proteases and collagenase and the increase was greater for follicle tissues from the stigma region.”

“This production of collagenase is effectively and selectively prevented by the addition of progesterone (2.5 X 10-5M) or the potent synthetic progesterone analogue, medroxyprogesterone acetate (1 X 10-6M).”

“ Progesterone at a concentration of 25 × 10 −6 m reduced the level of active collagenase by approximately 50%, whereas, total enzyme levels (active + latent) remained essentially constant during the first 3 days of culture.”