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Discover Supplement-Drug Interactions
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Last Updated: 3 years ago
supplement:
Progesterone
drug:
Colforsin
Research Papers that Mention the Interaction
“In the presence of forskolin , HOTT cell production of androstenedione, 17OHP, and progesterone increased by approximately 4.5-, 35-, and 3-fold, respectively.”
Bone morphogenetic protein inhibits ovarian androgen production.“Stimulation with forskolin increased the expression of the steroidogenic markers, which was accompanied by the production of pregnenolone and progesterone by HTPCs in vitro.”
“ Forskolin inhibited MMP-9 activity and increased TIMP-1 and progesterone secretion in both groups.”
“Moreover, progesterone inhibited forskolin-induced transcriptional activation of CRE-CRE-tk-CAT.”
“ Progesterone inhibited forskolin-induced transcriptional activation of hCGalpha gene.”
“ Forskolin , a direct activator of adenylate cyclase, increased progesterone levels 12-fold compared with non-stimulated cultures.”
“Treatment of monolayer cultures of HOTT cells with forskolin (0.01 to 20 mumol/L) or dbcAMP (0.01 to 1 mmol/L) for 48 h increased the production of androstenedione (8- to 15-fold) and progesterone (2- to 5-fold).”
“Treatment with forskolin or dibutyryl cAMP (dbcAMP) increased the production of progesterone and 17 alpha-hydroxyprogesterone as well as C19 steroids.”
“ Forskolin (10 microM) markedly increased production of both androstenedione (fivefold) and progesterone (threefold) as well as the activity of 3 beta HSD (sevenfold), and P450c17 (sevenfold) over basal.”
“Three clones tested all responded to forskolin and cholera toxin with up to 7-fold increases in progesterone secretion.”
“The enhanced progesterone levels stimulated by forskolin were also significantly inhibited by 10 IU IL-2 (P = 0.01).”
“Stimulation of the cyclase by forskolin or addition of 8-bromo-cAMP augments progesterone secretion by cultured cytotrophoblasts at least in part, by promoting accumulation of components of the cholesterol side-chain cleavage system.”
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