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“A previous study from our laboratory suggested that ER stress is promoted by progesterone in human endometrial cells, which suggests that progesterone may inhibit endometrial cell invasiveness by up-regulating ER stress.”
“Therefore, aberrant ER stress in response to progesterone may contribute to the altered invasiveness found in endometriotic tissues.”
“ConclusionsOur study suggests that pre-operative exposure to progesterone favourably modulates the effect of surgical stress , and this might underlie its beneficial effect when administered prior to surgery.”
Breast Cancer Research and Treatment • 2018 | View Paper
“Similarly, progesterone increased A20 and C/EBPβ expression through upregulation of ER stress in NESCs, resulting in inhibition of NF-κB activity and IL-6 and COX2 production.”