Possible Interaction: Progesterone and Beta Carotene

“Moreover, plasma, FF and CL beta-carotene levels were positively correlated with plasma progesterone levels.”

“Dogs fed 50 mg of beta-carotene had significantly higher concentrations of plasma progesterone between d 12 and 26 compared with unsupplemented dogs.”

“Furthermore, dietary beta-carotene increased plasma progesterone concentrations during the estrous cycle.”

“However, cells treated with LH plus beta-carotene or dbcAMP plus beta-carotene both produced significantly (P<0.01) less progesterone relative to those cells treated with LH or dbcAMP alone on days 7, 9 and 11 of culture.”

“These results indicate that beta-carotene can enhance luteal steroidogenesis when present at low concentrations but is inhibitory at higher concentrations and that encapsulation of beta-carotene in cyclodextrin is an effective method of supplying it to cells in culture.”

“Treatment of cells with 1 or 2 micromol/l beta-carotene resulted in sharp inhibition of progesterone production.”

“Medium was replaced after 24 h, thereafter medium was changed every 48 h. Treatment of cells with DMSO alone or with beta-carotene (5 micromol/l) in DMSO both resulted in significant (P<0.01) stimulation of progesterone production.”

“As compared to their respective controls, all concentrations of retinoic acid and beta-carotene increased progesterone content in the media.”

“Long-term supplementation of B-car increased prepartum plasma progesterone but had no effect on postpartum fertility.”