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Discover Supplement-Drug Interactions
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Last Updated: 4 years ago
supplement:
Progesterone
drug:
Afimoxifene
Research Papers that Mention the Interaction
“The … antiestrogen 4-hydroxytamoxifen at 10(-6) mol/L (a finding consistent with the reported … affected by the antiandrogen 4-hydroxyflutamide at 10(-6) mol/L. Progesterone (10(-7) mol/L) also lowered the effects of dehydroepiandrosterone (10(-…/L), as well as those of estradiol (10(-8) mol/L).”
C19 adrenal steroids enhance prostaglandin F2 alpha output by human endometrium in vitro.“The decrease in progesterone is significant in the myometrium and in the whole uterus (respectively P < 0.001 and P < 0.01), 24 hours after administration of 4-hydroxytamoxifen.”
Increase of myometrial activity correlated with variations in 17 beta-estradiol and progesterone uterine concentrations in mid-term pregnant rat: estrogen agonist effect of 4-hydroxytamoxifen.
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