Possible Interaction: Progesterone and Adrenocorticotropic Hormone

“In …, progesterone significantly increased the secretion of cortisol compared with estradiol [area under the curve (t(74) = 3.1; P < 0.01)] and urinary free cortisol (t(74) = 3.2; P < 0.01) and ACTH compared with hypogonadism [area under the curve (t(74) = 2.4; P < 0.05)].”

“ ACTH treatment caused a significant increase in plasma levels of cortisol, progesterone , androstenedione and testosterone in all mares (P<0.05).”

“ ACTH administration increased both cortisol (P<0.001) and progesterone concentrations (P<0.01) compared to CTR group.”

“Previously it was reported that adrenocorticotropin ACTH ) displayed the ability to restrict the action of estradiol-17s in uterine growth and of progesterone in decidual development.”

“In postmenopausal women, strong positive correlations were found between progesterone and corticotropin (ACTH) or cortisol profiles.”

“Testosterone negatively correlated with salivary cortisol response in men, while progesterone negatively correlated with ACTH and cortisol responses in women.”

“ ACTH increased PER1 mRNA, BMAL1, StAR, and 3β-HSD protein levels, and cortisol and progesterone production.”

“Moreover, in patients with adenomas, cortisol, 17-OH progesterone , and androstenedione responses to corticotropin were significantly increased (P < 0.001, all), whereas dehydroepiandrosterone sulfate levels were significantly lower at baseline, with blunted response to corticotropin (P < 0.001, both).”

“In the parents and two brothers the progesterone responses to ACTH were exaggerated.”

“ ACTH caused significant increases in the productions of pregnenolone (P5), progesterone (P4), 17-hydroxypregnenolone (17-OH-P5), 17-hydroxyprogesterone (17-OH-P4), DHEA, DHEA-S, androstenedione (delta 4-A), and cortisol.”