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Discover Supplement-Drug Interactions

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Last Updated: 9 months ago

Possible Interaction: Progesterone and Abiraterone

supplement:

Progesterone

Research Papers that Mention the Interaction

RESULTS Ab raterone tr eatment resulted in significant reduction in the intracellular levels of 17-OH pro gesterone an d DHT in both LnCap and PC3 cells.
Journal of B.U.ON. : official journal of the Balkan Union of Oncology  •  2020  |  View Paper
However, abiraterone increases progesterone , which can activate certain mutant androgen receptors (AR) identified previously in flutamide-resistant tumors.
Clinical Cancer Research  •  2014  |  View Paper
Abiraterone treatment decreased testosterone production but increased several precursor steroids in both classical and backdoor pathways in the presence of progesterone.
The combination of abiraterone and dutasteride decreased testosterone and DHT in the presence of progesterone but increased DHT in the absence of progesterone.
The Journal of Steroid Biochemistry and Molecular Biology  •  2014  |  View Paper
Similarly, it has been suggested that abiraterone acetate efficacy may be related to its ability to alter intratumoral concentrations of estrogen and progesterone.
Progres en urologie : journal de l'Association francaise d'urologie et de la Societe francaise d'urologie  •  2013  |  View Paper