supp.ai
Discover Supplement-Drug Interactions
Disclaimer: The information contained herein should NOT be used as a substitute for the advice of an appropriately qualified and licensed physician or other health care provider. The tool is not a substitute for the care provided… (more)
Last Updated: 3 years ago
supplement:
Progesterone
drug:
Abiraterone
Research Papers that Mention the Interaction
“RESULTS Ab raterone tr eatment resulted in significant reduction in the intracellular levels of 17-OH pro gesterone an d DHT in both LnCap and PC3 cells.”
“However, abiraterone increases progesterone , which can activate certain mutant androgen receptors (AR) identified previously in flutamide-resistant tumors.”
“ Abiraterone treatment decreased testosterone production but increased several precursor steroids in both classical and backdoor pathways in the presence of progesterone.”
“The combination of abiraterone and dutasteride decreased testosterone and DHT in the presence of progesterone but increased DHT in the absence of progesterone.”
“Similarly, it has been suggested that abiraterone acetate efficacy may be related to its ability to alter intratumoral concentrations of estrogen and progesterone.”
[CYP17A1 inhibitors in prostate cancer: mechanisms of action independent of the androgenic pathway].
Help us improve supp.ai, we'd love to hear your feedback: Submit Feedback