Allen Institute for Artificial Intelligence logo

Discover Supplement-Drug Interactions

Disclaimer: The information contained herein should NOT be used as a substitute for the advice of an appropriately qualified and licensed physician or other health care provider. The tool is not a substitute for the care provided… (more)
Last Updated: 2 years ago

Possible Interaction: Progesterone and 11 Beta-(4-Dimethylaminophenyl)-17 Alpha-Hydroxy-17 Beta-(3-Hydroxypropyl)-13 Alpha-Methyl-4,9-Gonadien-3-One

Research Papers that Mention the Interaction

The progesterone antagonists ZK98299 ( Onapristone ) and RU 486 (Mifepristone) inhibit the transcriptional activity of PR by complex mechanisms at concentrations much lower than the progestins.
The Journal of the Society for Gynecologic Investigation: JSGI  •  2000  |  View Paper
The antiprogestin, onapristone , partially blocked the ability of progesterone to prevent stimulation of MMP-3 by IL-1alpha.
The Journal of clinical endocrinology and metabolism  •  2000  |  View Paper
BACKGROUND A number of compounds, antiprogestins, e.g. mifepristone, onapristone and lilopristone, have been developed which compete with progesterone at the receptor level.
Acta obstetricia et gynecologica Scandinavica. Supplement  •  1997  |  View Paper
Interestingly, in contrast to ZK 136798, ON reduced the preovulatory increase in progesterone secretion.
These results clearly indicate: (a) that antiovulatory potency and antiprogestational activity may not be correlated in the rat; and (b) that decreased preovulatory levels of progesterone following treatment with ON may play an important role in intraovarian mechanism(s) contributing to a blocking of ovulation.
The Journal of Steroid Biochemistry and Molecular Biology  •  1996  |  View Paper