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Last Updated: 3 years ago
Possible Interaction: Progesterone and 11 Beta-(4-Dimethylaminophenyl)-17 Alpha-Hydroxy-17 Beta-(3-Hydroxypropyl)-13 Alpha-Methyl-4,9-Gonadien-3-One
Research Papers that Mention the Interaction
“The progesterone antagonists ZK98299 ( Onapristone ) and RU 486 (Mifepristone) inhibit the transcriptional activity of PR by complex mechanisms at concentrations much lower than the progestins.”
Novel Mechanisms of Progesterone Antagonists and Progesterone Receptor“The antiprogestin, onapristone , partially blocked the ability of progesterone to prevent stimulation of MMP-3 by IL-1alpha.”
“BACKGROUND A number of compounds, antiprogestins, e.g. mifepristone, onapristone and lilopristone, have been developed which compete with progesterone at the receptor level.”
“Interestingly, in contrast to ZK 136798, ON reduced the preovulatory increase in progesterone secretion.”
“These results clearly indicate: (a) that antiovulatory potency and antiprogestational activity may not be correlated in the rat; and (b) that decreased preovulatory levels of progesterone following treatment with ON may play an important role in intraovarian mechanism(s) contributing to a blocking of ovulation.”
The antiovulatory activity of progesterone antagonists is not correlated to their antiprogestational potency in the rat
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