Possible Interaction: Proflavine and Tryptophan

“Chemical modification of approximately four tryptophans or approximately four tyrosines per enzyme also caused analogous differential losses of clotting vs. synthetic substrate activities and reduced proflavin binding approximately 5- and approximately 10-fold, respectively.”

“Synchronous fluorescence studies showed that proflavine altered the microenvironment around the tryptophan residues to a greater extent than the tyrosine residues.”