Allen Institute for Artificial Intelligence
supp.ai logo
supp.ai

Discover Supplement-Drug Interactions

Disclaimer: The information contained herein should NOT be used as a substitute for the advice of an appropriately qualified and licensed physician or other health care provider. The tool is not a substitute for the care provided… (more)
Last Updated: 8 months ago

Possible Interaction: Procaine and Tetracaine

supplement:

Procaine

Research Papers that Mention the Interaction

It is suggested that such patients should routinely avoid tetracaine and procaine , as cross-reactions between benzocaine and such caines occurred commonly.
American journal of contact dermatitis : official journal of the American Contact Dermatitis Society  •  1999  |  View Paper
The differences in action on conduction of tetracaine and procaine are noted, but no explanation for these differences is available.
Proceedings of the Society for Experimental Biology and Medicine. Society for Experimental Biology and Medicine  •  1953  |  View Paper
Tetracaine and dibucaine inhibit the binding with half-maximal inhibition (CI50) of 0.12 and 0.25 mm, respectively, while inhibition by benzocaine and procaine occurs with CI50 of about 10-fold higher.
The Journal of Membrane Biology  •  2004  |  View Paper
Procaine and tetracaine produced a reversible and concentration-dependent inhibition of NMDA-induced currents, but lidocaine showed little inhibition at 1 mM or less.
Anesthesia and analgesia  •  2002  |  View Paper
Procaine at 500 microM moderately retards exchange while procaine at 10 mM and tetracaine at 5 mM slightly accelerate exchange.
Biochemistry  •  1989  |  View Paper
Tetracaine inhibited high K+-evoked [2,3-3H]GABA release from synaptosomes of rat brain in a dose-dependent manner with a minimal effective concentration of 10(-4) M. Cocaine, lidocaine, and procaine also reduced the release, although they were less potent than tetracaine.
Anesthesiology  •  1983  |  View Paper
Tetracaine and procaine inhibited 5-HT oxidation competitively, whereas dibucaine inhibited it non-competitively.
Japanese journal of pharmacology  •  1982  |  View Paper