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Discover Supplement-Drug Interactions
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Last Updated: 3 years ago
supplement:
Procaine
drug:
Tetracaine
Research Papers that Mention the Interaction
“It is suggested that such patients should routinely avoid tetracaine and procaine , as cross-reactions between benzocaine and such caines occurred commonly.”
A 10-year retrospective study on benzocaine allergy in the United Kingdom.“The differences in action on conduction of tetracaine and procaine are noted, but no explanation for these differences is available.”
“ Tetracaine and dibucaine inhibit the binding with half-maximal inhibition (CI50) of 0.12 and 0.25 mm, respectively, while inhibition by benzocaine and procaine occurs with CI50 of about 10-fold higher.”
The interaction of local anesthetics with the ryanodine receptor of the sarcoplasmic reticulum“ Procaine and tetracaine produced a reversible and concentration-dependent inhibition of NMDA-induced currents, but lidocaine showed little inhibition at 1 mM or less.”
“ Procaine at 500 microM moderately retards exchange while procaine at 10 mM and tetracaine at 5 mM slightly accelerate exchange.”
“ Tetracaine inhibited high K+-evoked [2,3-3H]GABA release from synaptosomes of rat brain in a dose-dependent manner with a minimal effective concentration of 10(-4) M. Cocaine, lidocaine, and procaine also reduced the release, although they were less potent than tetracaine.”
“ Tetracaine and procaine inhibited 5-HT oxidation competitively, whereas dibucaine inhibited it non-competitively.”
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