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Last Updated: 8 months ago

Possible Interaction: Procaine and Serotonin

supplement:

Procaine

Research Papers that Mention the Interaction

Procaine also inhibited uptake of norepinephrine (NE) and serotonin ( 5-HT) by the norepinephrine transporter (NET) or serotonin transporter (SERT) expressed in COS cells.
Naunyn-Schmiedeberg's Archives of Pharmacology  •  1999  |  View Paper
Certain other drugs (bufotenine, procaine , S-decylisothiourea) antagonized the depressor action of phenyldiguanide as well as the reflex depressor action of 5-hydroxytryptamine.
British journal of pharmacology and chemotherapy  •  1959  |  View Paper
Studies in laboratory animals have shown that procaine raises dopamine and serotonin levels in the brain.
Acta oto-laryngologica  •  2018  |  View Paper
The levels of dopamine (DA) and serotonin ( 5-HT) in the spinal cord were time-dependently increased after procaine (170 mg/kg, i.p.),
These results suggest that procaine causes significant elevations of rat spinal DA and 5-HT in the convulsive process and suggest that dopaminergic and serotonergic neurons may be associated with procaine-induced convulsions.
Japanese journal of pharmacology  •  1989  |  View Paper
Microiontophoretic application of cocaine, but not procaine , also depressed spontaneous cell firing of 5-HT-containing neurons and potentiated the inhibitory effects of 5-HT in the dorsal raphe nucleus.
European journal of pharmacology  •  1988  |  View Paper
Tetracaine and procaine inhibited 5-HT oxidation competitively, whereas dibucaine inhibited it non-competitively.
Tetracaine and procaine inhibited 5-HT oxidation much more than beta-phenylethylamine (PEA) oxidation.
Japanese journal of pharmacology  •  1982  |  View Paper
Procaine induced elevations of serotonin , norepinephrine, and dopamine; norepinephrine elevation occurred in a few brain parts, whereas serotonin and dopamine levels were elevated in all brain regions.
Journal of dental research  •  1981  |  View Paper
Procaine was found to be a competitive inhibitor of the deamination of 5-hydroxy-tryptamine (5-HT), tyramine, β-phenethylamine and benzylamine.
Biochemical pharmacology  •  1980  |  View Paper
Other drugs which are "membrane stabilizers-labilizers" such as trihexyphenidyl and procaine also promoted skeletal muscle necrosis when given prior to 5-HT.
Journal of the Neurological Sciences  •  1976  |  View Paper