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Discover Supplement-Drug Interactions
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Last Updated: 3 years ago
Research Papers that Mention the Interaction
“ Procaine also inhibited uptake of norepinephrine (NE) and serotonin ( 5-HT) by the norepinephrine transporter (NET) or serotonin transporter (SERT) expressed in COS cells.”
Selective inhibition of monoamine neurotransmitter transporters by synthetic local anesthetics“Certain other drugs (bufotenine, procaine , S-decylisothiourea) antagonized the depressor action of phenyldiguanide as well as the reflex depressor action of 5-hydroxytryptamine.”
“Studies in laboratory animals have shown that procaine raises dopamine and serotonin levels in the brain.”
“The levels of dopamine (DA) and serotonin ( 5-HT) in the spinal cord were time-dependently increased after procaine (170 mg/kg, i.p.),”
“These results suggest that procaine causes significant elevations of rat spinal DA and 5-HT in the convulsive process and suggest that dopaminergic and serotonergic neurons may be associated with procaine-induced convulsions.”
Some correlations between procaine-induced convulsions and monoamines in the spinal cord of rats.“Microiontophoretic application of cocaine, but not procaine , also depressed spontaneous cell firing of 5-HT-containing neurons and potentiated the inhibitory effects of 5-HT in the dorsal raphe nucleus.”
“Tetracaine and procaine inhibited 5-HT oxidation competitively, whereas dibucaine inhibited it non-competitively.”
“Tetracaine and procaine inhibited 5-HT oxidation much more than beta-phenylethylamine (PEA) oxidation.”
“ Procaine induced elevations of serotonin , norepinephrine, and dopamine; norepinephrine elevation occurred in a few brain parts, whereas serotonin and dopamine levels were elevated in all brain regions.”
“ Procaine was found to be a competitive inhibitor of the deamination of 5-hydroxy-tryptamine (5-HT), tyramine, β-phenethylamine and benzylamine.”
“Other drugs which are "membrane stabilizers-labilizers" such as trihexyphenidyl and procaine also promoted skeletal muscle necrosis when given prior to 5-HT.”
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