Possible Interaction: Procaine and Calcium Supplement

“Microelectrophoretic methods were also used to study the effect of PRHCL (8 × 10−4 and 8 × 10−2M) on RBC membrane calcium binding, with the results indicating that PRHCL competes with calcium for neuraminate binding sites.”

“ Procaine HCl was more efficient than PABA in inhibiting calcium uptake at equimolar concentrations.”

“… procaine and tetracaine not only affect key steps of the Ca-… also exert an indirect effect on membrane permeability to calcium and suggest that the consequent myoplasmic calcium increase induced by the anesthetics might account …, such as sustained contraction and eventual rigidity of both fast-twitch and masticatory muscles.”

“Lower concentrations of tetracaine (0.5mm) and procaine (⩽10mm) blocked contractions due to caffeine (at pCa ⩾6.73), sulphydryl oxidizing agents, or Ca2+ -induced Ca2+ release (CICR).”

“ Procaine (0.3mM) reversibly decreased the amplitude and the rate of rise of the calcium transient.”

“The caffeine‐evoked intracellular calcium increase was reduced by two inhibitors of calcium‐induced calcium release, ryanodine and procaine.”

“ Procaine slowed down the rate of calcium uptake by SR vesicles without enhancing the vesicles' passive permeability.”

“ Procaine (5 mM), which blocks release of calcium from intracellular stores, produced an effect on somatostatin secretion similar to that of BAPTA/AM.”

“ Procaine , on the other hand, caused a significant increase (P less than 0.01) in the unidirectional influx of calcium across the rat intestinal cells.”

“Furthermore, procaine inhibits the release of Ca from the store site, with no effect on the contractile protein.”