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Discover Supplement-Drug Interactions
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Last Updated: 3 years ago
drug:
Procainamide
supplement:
Quinidine
Research Papers that Mention the Interaction
“The overall concordant response rate to intravenous procainamide and oral quinidine was 56% (28 of 50 patients).”
Usefulness of the response to intravenous procainamide during electrophysiologic study in predicting the response to oral quinidine in patients with inducible sustained monomorphic ventricular tachycardia associated with coronary artery disease.“Thus, although neither procainamide nor quinidine appear to have had a benefit on mortality, the effect of procainamide appears to be significantly worse than that of quinidine.”
“Analyses demonstrated no increase in all-cause mortality for quinidine and mexiletine over placebo, but a trend toward higher mortality with procainamide.”
“Dose response curves, plotting change in MAPD90 versus plasma drug level, showed strong linear correlation for both procainamide (p less than 0.0001) and quinidine (p less than 0.0001).”
“Thus, the antiarrhythmic effects of quinidine and procainamide are additive.”
“Clinical toxicity occasionally occurred with the increase in serum levels of quinidine and procainamide , and the dose of these drugs should be decreased when amiodarone is administered concurrently.”
“In digitalized patients, quinidine increases serum digoxin concentration, increases digoxin's effect on atrioventricular conduction, and produces more adverse gastrointestinal effects than procainamide , disopyramide, or mexiletine.”
“ Procainamide and quinidine both tended to prolong the effective refractory period of atrial, ventricular, and accessory pathway tissue as well as to slow antegrade and retrograde conduction in the accessory pathway.”
“Though adequate and even high drug blood levels were reached, an effective antiarrhythmic response was observed in only eight patients receiving procaine amide and in seven of those taking quinidine.”
“Considering that the therapeutic doses of procaine amide are generally larger than those of quinidine , the negative inotropic effect of the former is therapeutically more significant than that of the latter.”
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