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Last Updated: 3 months ago

Possible Interaction: Procainamide and Quinidine

supplement:

Quinidine

Research Papers that Mention the Interaction

The overall concordant response rate to intravenous procainamide and oral quinidine was 56% (28 of 50 patients).
The American journal of cardiology  •  1993  |  View Paper
Thus, although neither procainamide nor quinidine appear to have had a benefit on mortality, the effect of procainamide appears to be significantly worse than that of quinidine.
The American journal of cardiology  •  1991  |  View Paper
Analyses demonstrated no increase in all-cause mortality for quinidine and mexiletine over placebo, but a trend toward higher mortality with procainamide.
The American journal of cardiology  •  1991  |  View Paper
Dose response curves, plotting change in MAPD90 versus plasma drug level, showed strong linear correlation for both procainamide (p less than 0.0001) and quinidine (p less than 0.0001).
The American journal of cardiology  •  1988  |  View Paper
Thus, the antiarrhythmic effects of quinidine and procainamide are additive.
The American journal of cardiology  •  1985  |  View Paper
Clinical toxicity occasionally occurred with the increase in serum levels of quinidine and procainamide , and the dose of these drugs should be decreased when amiodarone is administered concurrently.
The American journal of cardiology  •  1984  |  View Paper
In digitalized patients, quinidine increases serum digoxin concentration, increases digoxin's effect on atrioventricular conduction, and produces more adverse gastrointestinal effects than procainamide , disopyramide, or mexiletine.
Annals of internal medicine  •  1980  |  View Paper
Procainamide and quinidine both tended to prolong the effective refractory period of atrial, ventricular, and accessory pathway tissue as well as to slow antegrade and retrograde conduction in the accessory pathway.
Circulation  •  1977  |  View Paper
Though adequate and even high drug blood levels were reached, an effective antiarrhythmic response was observed in only eight patients receiving procaine amide and in seven of those taking quinidine.
Circulation  •  1974  |  View Paper
Considering that the therapeutic doses of procaine amide are generally larger than those of quinidine , the negative inotropic effect of the former is therapeutically more significant than that of the latter.
The American journal of cardiology  •  1960  |  View Paper
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