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Discover Supplement-Drug Interactions
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Last Updated: 2 years ago
drug:
Procainamide
supplement:
Digitalis
Research Papers that Mention the Interaction
“This therapy may restore sinus rhythm, but conversion to sinus rhythm often requires the combined use of digitalis with a β-blocker or class I antiarrhythmic drug (quinidine, disopyramide, procainamide , propafenone, or flecainide).”
Antiarrhythmic Treatment of Atrial Arrhythmias“Both diphenylhydantoin sodium and procaine amide can suppress digitalis arrhythmias due to enhanced automaticity, but procaine amide may promote “re-entry” arrhythmias by potentiating the intraventricular conduction defect caused by the glycoside.”
“In three experiments, the ventricular tachycardia induced by digitalis was changed by procainamide to a slower, multifocal ventricular rhythm with widened complexes.”
Use of diphenylhydantoin sodium to dissociate the effects of procainamide on automaticity and conduction in the normal and arrhythmic heart.
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