Possible Interaction: Probucol and Vitamin E

“ Probucol reduced serum vitamin E by 14% (P < .001) secondary to cholesterol and triglyceride lowering.”

“Thus, it appears that although the antioxidant activity of probucol exceeds that of alpha-tocopherol for lipid oxidation, the reverse is true for protein degradation and, perhaps more significantly, for subsequent macrophage uptake.”

“Atherosclerotic arterial walls contain increased levels of redox‐active metal ions, and the LDL of …, possibly as a result of reduced endogenous antioxidants such as vitamin E. Dietary supplementation with vitamin E (… probucol reduce the oxidation rate of LDL and may …., Collen, D. Oxidized lipoproteins in atherosclerosis and thrombosis.”

“ Probucol and alpha-tocopherol at the same concentration exhibited a lesser inhibitory effect.”

“The antioxidant activity of probucol was less than that of alpha-tocopherol , but the difference between the two antioxidant activities was smaller in the membranes than in homogeneous solution.”

“In addition, a large amount of vitamin E supplementation eliminated the effect of probucol against P. yoelii XL-17 infection and lowered the effect of probucol on host plasma vitamin E concentration.”

“Thus, probucol which reduced plasma alpha-tocopherol concentration was effective in enhancing the host to resist malaria infection in mice.”

“In a mouse in vivo experiment, addition of 1% probucol to the diet decreased plasma alpha-tocopherol concentrations.”

“The repeated administration of alpha-tocopherol and probucol accelerated the ulcer healing and inhibited the increase in the TBA-reactive substance content in the ulcerated region.”

“Conclusion: These findings indicate that α-tocopherol and probucol suppress allergic responses in asthma model mice, although these two drugs cause suppression in different ways that are unrelated to antioxidation.”