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Last Updated: 9 months ago

Possible Interaction: Probucol and Vitamin E


Vitamin E

Research Papers that Mention the Interaction

Probucol reduced serum vitamin E by 14% (P < .001) secondary to cholesterol and triglyceride lowering.
Arteriosclerosis, thrombosis, and vascular biology  •  1995  |  View Paper
Thus, it appears that although the antioxidant activity of probucol exceeds that of alpha-tocopherol for lipid oxidation, the reverse is true for protein degradation and, perhaps more significantly, for subsequent macrophage uptake.
Free radical research  •  1994  |  View Paper
Atherosclerotic arterial walls contain increased levels of redox‐active metal ions, and the LDL of …, possibly as a result of reduced endogenous antioxidants such as vitamin E. Dietary supplementation with vitamin E (… probucol reduce the oxidation rate of LDL and may …., Collen, D. Oxidized lipoproteins in atherosclerosis and thrombosis.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology  •  1994  |  View Paper
Probucol and alpha-tocopherol at the same concentration exhibited a lesser inhibitory effect.
Life sciences  •  2000  |  View Paper
The antioxidant activity of probucol was less than that of alpha-tocopherol , but the difference between the two antioxidant activities was smaller in the membranes than in homogeneous solution.
Biochimica et biophysica acta  •  1992  |  View Paper
In addition, a large amount of vitamin E supplementation eliminated the effect of probucol against P. yoelii XL-17 infection and lowered the effect of probucol on host plasma vitamin E concentration.
Malaria Journal  •  2016  |  View Paper
Thus, probucol which reduced plasma alpha-tocopherol concentration was effective in enhancing the host to resist malaria infection in mice.
Parasitology Research  •  2015  |  View Paper
In a mouse in vivo experiment, addition of 1% probucol to the diet decreased plasma alpha-tocopherol concentrations.
The Journal of nutritional biochemistry  •  2010  |  View Paper
The repeated administration of alpha-tocopherol and probucol accelerated the ulcer healing and inhibited the increase in the TBA-reactive substance content in the ulcerated region.
European journal of pharmacology  •  2008  |  View Paper
Conclusion: These findings indicate that α-tocopherol and probucol suppress allergic responses in asthma model mice, although these two drugs cause suppression in different ways that are unrelated to antioxidation.
International Archives of Allergy and Immunology  •  2006  |  View Paper
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