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Discover Supplement-Drug Interactions
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Last Updated: 3 years ago
drug:
Probucol
supplement:
Cupric Cation
Research Papers that Mention the Interaction
“Otherwise, KR 31372 and probucol strongly inhibited the production of thiobarbituric acid reactive substances (TBARS) caused by the incubation of LDL with Cu2+ion , and significantly reduced the intracellular oxidative stress when stimulated with H2O2.”
KR 31372, a benzopyran derivative, inhibits oxidized LDL‐stimulated proliferation and migration of vascular smooth muscle cells“ Probucol markedly decreased the susceptibility of LDL and intermediate density lipoprotein plus very low density lipoprotein (IDL + VLDL) particles to oxidation, as measured by the production of conjugated dienes when adding Cu2+.”
“The effects of Cu2+ were inhibited by a number of lipophilic antioxidants, including probucol , vitamin E, butylated hydroxytoluene, and a 21-aminosteroid, U74389G.”
“The delay in Cu2+ -induced LDL oxidation with probucol corresponded to the time required for free radical-mediated processes to convert probucol to a spiroquinone and a diphenoquinone.”
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