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Discover Supplement-Drug Interactions

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Last Updated: 8 months ago

Possible Interaction: Probucol and Asymmetric Dimethylarginine

Research Papers that Mention the Interaction

In diabetics rats receiving probucol , the expressions of DDAH1 and ADMA were downregulated, whereas that of PRMT1 was upregulated.
Annals of palliative medicine  •  2021  |  View Paper
ConclusionIn summary, the present results suggest that the protective effect of probucol on endothelium is related to reduction of ADMA concentration by inhibition of PRMT I expression and enhancement of DDAH activity.
Probucol significantly decreased the level of ADMA , concomitantly with reduction of PRMT I expression and elevation of DDAH activity and up-regulation of eNOS expression.
Cardiovascular Drugs and Therapy  •  2006  |  View Paper
Probucol inhibited changes in ADMA levels evoked by either OxLDLs (p < 0.001) or BOXes (p < 0.01).
Journal of neurosurgery  •  2005  |  View Paper
Pretreatment with probucol significantly improved endothelium‐dependent relaxation, decreased concentrations of ADMA and MDA and increased nitrite/nitrate level in the rats treated with LDL.
British journal of pharmacology  •  2002  |  View Paper