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Discover Supplement-Drug Interactions
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Last Updated: 3 years ago
drug:
Probucol
supplement:
Asymmetric Dimethylarginine
Research Papers that Mention the Interaction
“In diabetics rats receiving probucol , the expressions of DDAH1 and ADMA were downregulated, whereas that of PRMT1 was upregulated.”
Abnormalities of the PRMT1-ADMA-DDAH1 metabolism axis and probucol treatment in diabetic patients and diabetic rats.“ConclusionIn summary, the present results suggest that the protective effect of probucol on endothelium is related to reduction of ADMA concentration by inhibition of PRMT I expression and enhancement of DDAH activity.”
“ Probucol significantly decreased the level of ADMA , concomitantly with reduction of PRMT I expression and elevation of DDAH activity and up-regulation of eNOS expression.”
“ Probucol inhibited changes in ADMA levels evoked by either OxLDLs (p < 0.001) or BOXes (p < 0.01).”
In vitro and in vivo effects of probucol on hydrolysis of asymmetric dimethyl L-arginine and vasospasm in primates.“Pretreatment with probucol significantly improved endothelium‐dependent relaxation, decreased concentrations of ADMA and MDA and increased nitrite/nitrate level in the rats treated with LDL.”
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