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Discover Supplement-Drug Interactions

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Last Updated: 8 months ago

Possible Interaction: Probenecid and Tryptophan



Research Papers that Mention the Interaction

The data indicate that during l-tryptophan treatment, plasma probenecid concentrations are reduced but that no significant alterations in cerebrospinal fluid probenecid concentrations occur.
Psychopharmacology  •  2004  |  View Paper
Probenecid caused an increase by 52% (P<0.01) in the free (non protein-bound) concentration of tryptophan in plasma (from 1.22±0.16 to 1.86±0,28 Μg/ml; mean±SEM).
Psychopharmacologia  •  2004  |  View Paper
In this study an attempt was made to establish whether probenecid also exerts an influence on the metabolism of the MA precursors: tryptophan and tyrosine.
Psychopharmacologia  •  2004  |  View Paper
A negative correlation is found between CSF probenecid and serum tryptophan.
Psychiatria clinica  •  1983  |  View Paper
Preloading animals with both tryptophan and probenecid increased the apparent transport of lactate, probenecid and 5HIAA but not the transport of glucose.
Neurochemical Research  •  2004  |  View Paper
On the other hand, it is concluded that probenecid is able to inhibit the excretion from the brain of some acid compounds including tyrosine, tryptophan and DOPA.
Biulleten' eksperimental'noi biologii i meditsiny  •  1989  |  View Paper
The binding was competitively inhibited by probenecid and L-tryptophan.
European journal of biochemistry  •  1985  |  View Paper
Reserpine reduced levels of 5-HT and NADA whereas probenecid caused a marked reduction in TP and slight elevation of NADA levels.
Comparative biochemistry and physiology. C, Comparative pharmacology and toxicology  •  1984  |  View Paper
Brain tryptophan concentration was also markedly increased by phenmetrazine, phenelzine, dl -fenfluramine, bulbocapnine, γ-hydroxybutyrate and probenecid.
The Journal of pharmacology and experimental therapeutics  •  1971  |  View Paper