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Discover Supplement-Drug Interactions
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Last Updated: 5 years ago
drug:
Probenecid
supplement:
Tryptophan
Research Papers that Mention the Interaction
“The data indicate that during l-tryptophan treatment, plasma probenecid concentrations are reduced but that no significant alterations in cerebrospinal fluid probenecid concentrations occur.”
The effect of l-tryptophan administration on the concentration of probenecid in plasma and cerebrospinal fluid in patients“ Probenecid caused an increase by 52% (P<0.01) in the free (non protein-bound) concentration of tryptophan in plasma (from 1.22±0.16 to 1.86±0,28 Μg/ml; mean±SEM).”
“In this study an attempt was made to establish whether probenecid also exerts an influence on the metabolism of the MA precursors: tryptophan and tyrosine.”
“A negative correlation is found between CSF probenecid and serum tryptophan.”
“Preloading animals with both tryptophan and probenecid increased the apparent transport of lactate, probenecid and 5HIAA but not the transport of glucose.”
“On the other hand, it is concluded that probenecid is able to inhibit the excretion from the brain of some acid compounds including tyrosine, tryptophan and DOPA.”
[Effect of ethanol and probenecid on the excretory function of the cerebral choroid plexus in rats].“The binding was competitively inhibited by probenecid and L-tryptophan.”
“Reserpine reduced levels of 5-HT and NADA whereas probenecid caused a marked reduction in TP and slight elevation of NADA levels.”
“ Brain tryptophan concentration was also markedly increased by phenmetrazine, phenelzine, dl -fenfluramine, bulbocapnine, γ-hydroxybutyrate and probenecid.”
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