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Discover Supplement-Drug Interactions

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Last Updated: 8 months ago

Possible Interaction: Probenecid and Riboflavin

supplement:

Riboflavin

Research Papers that Mention the Interaction

Benemid can inhibit transport of both PAH and riboflavin.
Proceedings of the Society for Experimental Biology and Medicine. Society for Experimental Biology and Medicine  •  1960  |  View Paper
The membrane transport inhibitor amiloride, but not 4,4'-diisothiocyanostilbene-2,2'-disulfonic acid, 4-acetamide-4'-isothiocyanostilbene-2,2'-disulfonic acid, furosemide, or probenecid , inhibited RF uptake in a competitive (inhibitory constant = 0.48 mM) and reversible manner.
The American journal of physiology  •  1994  |  View Paper
Probenecid decreased the renal clearance of riboflavin , and this effect was directly related to the serum concentration of the inhibitor.
Journal of pharmaceutical sciences  •  1970  |  View Paper
It appears that probenecid also inhibits the specialized transport process responsible for the intestinal absorption of riboflavin in man.
Oral administration of probenecid prior to intramuscular injection of FMN increased the apparent “half-life” of the initial rapid phase of riboflavin excretion.
The urinary recovery of riboflavin following oral or intramuscular administration of the vitamin was usually somewhat decreased by probenecid.
Journal of pharmaceutical sciences  •  1967  |  View Paper
The uptake of RF by BBM vesicles was, however, inhibited by probenecid and organic anion transport inhibitors, 4,4-diiso-thiocyanatostilbene-2,2-disulfonic acid (DIDS, 1 mM) and 4-acetamido-4-isothiocyanatostilbene-2,2-disulfonic acid (SITS, 1 mM).
Biochimica et biophysica acta  •  1997  |  View Paper
While the transmembrane transport inhibitors 4-acetamido-4'-isothiocyanatostilbene-2,2'-disulfonic acid (SITS), 4,4'-diisothiocyanatostilbene-2,2'-disulfonic acid (DIDS) and furosemide had no effect on RF uptake, amiloride and probenecid suppressed RF uptake in a dose-dependent fashion.
Biochimica et biophysica acta  •  1995  |  View Paper