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Discover Supplement-Drug Interactions

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Last Updated: 8 months ago

Possible Interaction: Probenecid and Folate

supplement:

Folate

Research Papers that Mention the Interaction

Vitamin B12 and folate supplementation may allow for further dose escalation of pralatrexate and probenecid.
Cancer Chemotherapy and Pharmacology  •  2005  |  View Paper
In an extension of these earlier studies, which had focused only … murine ascites tumors, we now report that parental co-administration of PBCD will also enhance net intracellular accumulation in vitro and intracellular persistence in vivo of a new folate analogue, 10-propargyl-10-deazaaminopterin (PDX) in tumor cells.
Clinical cancer research : an official journal of the American Association for Cancer Research  •  2000  |  View Paper
Transport of all folates studied was inhibited by probenecid and methotrexate.
The Journal of Biological Chemistry  •  2011  |  View Paper