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Discover Supplement-Drug Interactions
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Last Updated: 3 years ago
drug:
Probenecid
supplement:
Folate
Research Papers that Mention the Interaction
“Vitamin B12 and folate supplementation may allow for further dose escalation of pralatrexate and probenecid.”
A phase I clinical pharmacologic study of pralatrexate in combination with probenecid in adults with advanced solid tumors“In an extension of these earlier studies, which had focused only … murine ascites tumors, we now report that parental co-administration of PBCD will also enhance net intracellular accumulation in vitro and intracellular persistence in vivo of a new folate analogue, 10-propargyl-10-deazaaminopterin (PDX) in tumor cells.”
“Transport of all folates studied was inhibited by probenecid and methotrexate.”
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