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Discover Supplement-Drug Interactions

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Last Updated: 8 months ago

Possible Interaction: Probenecid and Calcium Supplement

Research Papers that Mention the Interaction

Probenecid , an activator of TRPV2, induced an increase in intracellular Ca2+ ( Ca2+i ), an effect that may be attenuated or abolished by the TRPV2 blocker ruthenium red.
The alteration of Ca2+i by probenecid or 4α‐phorbol 12‐13‐dicprinate was dramatically inhibited in cells infected with TRPV2 short hairpin RNA (shRNA) or TRPV4 shRNA.
Journal of cellular and molecular medicine  •  2016  |  View Paper
In 1970, Garcia and Yendt reported that probenecid , a commonly employed uricosuric agent in gout, was found to increase calcium excretion in two patients with idiopathic hypercalciuria (3).
Israel journal of medical sciences  •  1983  |  View Paper
Probenecid , included in the buffers to prevent extrusion of Fura-2 dye from cells, was found to interfere with the EGTA-chelation of calcium , required to determine Rmin for quantitation of [Ca2+]i.
Journal of molecular endocrinology  •  2021  |  View Paper