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Discover Supplement-Drug Interactions
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Last Updated: 3 years ago
drug:
Probenecid
supplement:
Calcium Supplement
Research Papers that Mention the Interaction
“ Probenecid , an activator of TRPV2, induced an increase in intracellular Ca2+ ( Ca2+i ), an effect that may be attenuated or abolished by the TRPV2 blocker ruthenium red.”
“The alteration of Ca2+i by probenecid or 4α‐phorbol 12‐13‐dicprinate was dramatically inhibited in cells infected with TRPV2 short hairpin RNA (shRNA) or TRPV4 shRNA.”
Functional TRPV2 and TRPV4 channels in human cardiac c‐kit+ progenitor cells“In 1970, Garcia and Yendt reported that probenecid , a commonly employed uricosuric agent in gout, was found to increase calcium excretion in two patients with idiopathic hypercalciuria (3).”
“ Probenecid , included in the buffers to prevent extrusion of Fura-2 dye from cells, was found to interfere with the EGTA-chelation of calcium , required to determine Rmin for quantitation of [Ca2+]i.”
Quantitative high-throughput assay to measure MC4R-induced intracellular calcium
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