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Discover Supplement-Drug Interactions
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Last Updated: 3 years ago
drug:
Prenylamine
supplement:
Calcium Supplement
Research Papers that Mention the Interaction
“The calcium induced increase in ATPase and the rate of calcium uptake of the vesicular fragments of sarcoplasmic reticulum isolated from rabbit skeletal muscle are reduced by reserpine, prenylamine , chlorpromazine and imipramine.”
The inhibition of the sarcoplasmic calcium pump by prenylamine, reserpine, chlorpromazine and imipramine“The type of antagonism between verapamil, nifedipine or prenylamine and calcium or isoproterenol on myocardial contractility, was investigated in cat papillary muscles.”
“It seems that, in acute models, PNL acts as a calcium antagonistic drug rather than an adrenergic moderator.”
“5 It is suggested that the inhibitory effects of prenylamine , chlorpromazine and No. 233 may be attributed mainly to the Ca antagonistic effect whereas W‐7 may inhibit the process beyond the transmembrane Ca influx.”
“ Prenylamine reduced the passive binding and the active uptake and released already bound calcium.”
“The slow (secondary) inward current carried by calcium and/or sodium and the steady-state outward current are also depressed by prenylamine.”
“Conversely Ca antagonistic compounds such as verapamil, D 600 or prenylamine which reduce the transmembrane Ca influx into the heart muscle cells, can prevent high energy phosphate deficiency and cardiac lesions.”
“Reserpine and prenylamine (each 6 × 10−5 M) inhibited the ATP-Mg++-dependent uptake of noradrenaline by the vesicles as well as the Ca++ and Mg++ stimulated ATPase.”
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