Possible Interaction: Pregnanolone and Progesterone

“Plasma progesterone, allopregnanolone, and pregnanolone concentrations increased with increasing progesterone dose.”

“These data suggest that allopregnanolone and pregnanolone may contribute to or mediate the observed behavioral effects of progesterone.”

“The aim of this study is to compare severity of negative mood between women receiving different serum allopregnanolone concentrations during progesterone treatment.”

“Control subjects in the follicular and luteal phase showed a significant reduction in SEV after pregnanolone injections compared to vehicle.”

“We conclude that progesterone treatment increases brain allopregnanolone concentrations, but also increases cortisol levels in males, which may disrupt developmental processes.”

“ Progesterone increased the levels of DHP and THP in plasma and hippocampus and prevented kainic-acid-induced neuronal loss.”

“ Progesterone treatment caused a 60-fold increase in THP in the culture medium.”

“In cultures of neonatal Schwann cells (the peripheral nervous system elements involved in the synthesis of myelin), the addition of progesterone and of dihydroprogesterone significantly increases Po gene expression; the 3alpha-reduced metabolite of dihydroprogesterone, tetrahydroprogesterone proved to be even more effective.”

“ THP rapidly antagonized the stimulatory effect of PS, but progesterone inhibited the contractions after a delay, suggesting that the known 'silencing' actions of progesterone on the uterus could be mediated via the metabolite THP, which potentiates the inhibitory function of GABAA receptors.”