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Discover Supplement-Drug Interactions

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Last Updated: 8 months ago

Possible Interaction: Pregnanolone and 4-Hydroxybutyric Acid

Research Papers that Mention the Interaction

In the rat brain, gamma-hydroxybutyric-acid GHB ) increases the concentrations of 3alpha-hydroxy,5alpha-pregnan-20-one (allopregnanolone, 3alpha,5alpha-THP) and 3alpha,21-dihydroxy,5alpha-pregnan-20-one (allotetrahydrodeoxycorticosterone/3alpha,5alphaTHDOC), two neurosteroids acting as positive allosteric modulators of gamma-aminobutyric acid (GABA)(A) receptors.
Neuropharmacology  •  2005  |  View Paper