Possible Interaction: Pregabalin and D-Serine

“Although the precise mechanism for the effect of PGB on d-serine metabolism and abundance is unknown, the antinociceptive action of PGB likely involves the reduction of spinal d-serine content and subsequent attenuation of NMDA receptor-mediated synaptic transmission in the superficial dorsal horn.”

“Furthermore, bath-applied d-serine attenuated the effects of PGB treatment.”

“Substantial evidence suggests that d-serine , an endogenous co-agonist at the strychnine-insensitive glycine site of the NMDA receptor, counteracts the antinociceptive actions of PGB at the level of the spinal cord.”