Possible Interaction: Prednisone and Adrenocorticotropic Hormone

“ Prednisone administration was also associated with significant decreases in plasma levels of adrenocorticotropic hormone (ACTH), cortisol, and 3-methoxy,4-hydroxyphenyl glycol (MHPG) and in cerebrospinal fluid (CSF) levels of ACTH, beta-endorphin (BE), beta-lipotropin (BLPH), somatostatin-like immunoreactivity (SLI), and norepinephrine (NE).”

“ Prednisone administration was associated with decreases in cerebrospinal fluid levels of corticotropin , norepinephrine, beta-endorphin, beta-lipotropin, and somatostatinlike immunoreactivity.”

“ Prednisone administration results in a decrease in ACTH secretion by the anterior pituitary, suppressing synthesis of glucocorticoids, DHEA, and DHEA metabolites.”

“The patients' oCRH-stimulated ACTH and cortisol levels on the day off prednisone did not differ from normal levels, but were significantly blunted during the day on prednisone (P less than 0.05).”

“Perhaps, most convincingly, adrenocorticotrophic hormone can control fits in adrenal suppressed patients, including those concurrently on prednisone , even in the presence of documented low serum cortisol concentrations.”

“In infants receiving prednisone and then prednisone plus ACTH , serum cortisol was suppressed to about one‐quarter of baseline levels with the initiation of prednisone, and remained suppressed during ACTH administration.”

“In the subjects without evidence of adrenocortical hyperfunction, a significant suppression of the adrenocortical response to corticotropin was uniformly noted following the administration of prednisone.”